Academics divided over vitamin D study claims of cold and flu protection

The study aimed to assess the overall effect of vitamin D supplements on risk of acute respiratory tract infection. © iStock

Vitamin D supplements could help prevent acute respiratory tract infections, including colds and flu, according to a study in The BMJ. But a linked editorial penned by academics from New Zealand and Scotland argues the results are “not sufficiently applicable to the general population.”

Led by researchers from Queen Mary University of London, the BMJ study recommends “support the introduction of public health measures such as food fortification to improve vitamin D status in settings where profound vitamin D deficiency is common.”

But others say a clinically useful effect remains uncertain and needs confirmation.

In a linked editorial, Mark Bolland from the University of Auckland and Alison Avenell from the University of Aberdeen, who recently questioned the evidence for use of vitamin D supplements to prevent disease, say a clinically useful effect remains uncertain and requires confirmation in well-designed adequately powered randomised controlled trials.

The study assessed the overall effect of vitamin D supplements on risk of acute respiratory tract infection in a systematic review and meta-analysis of individual participant data from 25 randomised controlled trials of vitamin D supplementation, involving 11,321 participants aged 0 to 95 years.

They found that vitamin D supplementation resulted in a 12% reduction in the proportion of participants experiencing at least one acute respiratory tract infection.

Our study reports a major new indication for vitamin D supplementation: the prevention of acute respiratory tract infection," wrote the authors. "We also show that people who are very deficient in vitamin D and those receiving daily or weekly supplementation without additional bolus doses experienced particular benefit. Our results add to the body of evidence supporting the introduction of public health measures such as food fortification to improve vitamin D status, particularly in settings where profound vitamin D deficiency is common.”

Further analyses among specific groups showed benefits are greater in those receiving daily or weekly vitamin D without additional large doses. They added the protective effects were strongest among those with severe vitamin D deficiency (less than 25 nmol/L baseline blood levels).

Headline view questioned

However, in a linked editorial, Bolland and Avenell question the headline finding of the study – namely the 12% reduction in the odds of an acute respiratory tract infection from supplementation.

“There are reasons for viewing the headline result cautiously,” they wrote. “In absolute terms, the primary result is a reduction from 42% to 40% in the proportion of participants experiencing at least one acute respiratory tract infection. It seems unlikely that the general population would consider a 2% absolute risk reduction sufficient justification to take supplements."

“Furthermore, the definition of acute respiratory tract infection varied between studies, consisting of a mixture of diverse conditions such as acute otitis media, laboratory confirmed influenza, self-reported colds, parent reported colds or chest infections, or radiograph confirmed pneumonia. It is difficult to know whether a reduction in this mixture of conditions is applicable to the general population and how it should be interpreted clinically.”

They concluded that current evidence does not support the use of vitamin D supplementation to prevent disease, “except for those at high risk of osteomalacia (weak bones and muscles due to low blood vitamin D levels, currently defined as less than 25 nmol/L).”

Commenting on the research, Professor Louis Levy, head of nutrition science at Public Health England, noted that recent recent recommendations from the UK's Scientific Advisory Committee on Nutrition (SACN), suggest that certain population groups should take a daily 10 micrograms Vitamin D supplement year round and that everyone consider taking a supplement during the autumn and winter months to protect musculoskeletal health. 

However, she noted that the evidence on vitamin D and infection is inconsistent "and this study does not provide sufficient evidence to support recommending Vitamin D for reducing the risk of respiratory tract infections.”

In contrast, Dr Benjamin Jacobs, a consultant paediatrician at the Royal National Orthopaedic Hospital in the UK said the study is 'a major step forward' - adding that the BMJ study shows strong evidence of benefit and safety of vitamin D supplements from a rigorous analysis of 25 clinical trials.

“Martineau’s study shows a clear reduction in respiratory infection in people taking vitamin D, including patients of all age groups," said Jacombs. "The main caveat is the finding that vitamin D was only effective if given daily or weekly.  Large doses given once a month, or even less frequently, did not show benefit and may even be harmful."

He added that commentaries from Bolland and other sceptics 'try, but fail, to find weaknesses' in the analysis analysis. 

"Martineau’s data is strong, from 11,000 patients in good quality clinical trials around the world. The case for universal vitamin D supplements, or food fortification with vitamin D, is now undeniable," said Jacobs. "Governments and health professionals need to take Martineau’s study into account when setting Vitamin D policy now.”

Source: The BMJ
“Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
doi: https://doi.org/10.1136/bmj.i6583
Authors: Adrian R Martineau, et al
Linked editorial: BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.j456

Related News

Experts make the case for European vitamin D fortification strategy

Experts make the case for European vitamin D fortification strategy

Insufficient levels of vitamin D could lead to a higher risk of developing asthma. ©iStock

Vitamin D deficiency linked to higher risk of asthma in children: Korean study

© iStock

Malaysia study: Vitamin D deficiency risk for epileptic children

Warning over vitamin D deficiency in southern Australian youngsters

Warning over vitamin D deficiency in southern Australian youngsters

The study was the first to track vitamin D levels from birth to asthma onset. ©iStock

Kids with vitamin D deficiency more likely to develop asthma: 10-year study

People living in urban Beijing are at risk of severe vitamin D deficiency.

Targeted prevention needed to battle ‘severe’ vitamin D deficiencies in Chinese urban populations

Related Products

See more related products

Comments (2)

John - 19 Feb 2017 | 08:06

Vitamin D very helpful

With all the info out there I can't see how anyone would say the studies on Vitamin D are not definitive. Just look at www.grassrootshealth.net with their D'action program. They show that Vitamin D is essential to reducing the risk of many disease states.

19-Feb-2017 at 20:06 GMT

Marc - 17 Feb 2017 | 07:08

vitamin D does help prevent respiratory illness.

There is no doubt that vitamin D lessens the risk of respiratory illness, as Dr. John Cannell of the Vitamin D Council has been proving for years. Nevertheless, the natural source of vitamin D, sun exposure, may be even more important. If you observe the different countries or areas of the world and assess the risk of respiratory illness, you will note that those illness virtually disappear during the summer. Yet, sun exposure does so much more than just stimulate vitamin D production by the skin, and the health benefits go far beyond vitamin D. Here are a few scientifically-documented facts regarding the healthful effects of sun exposure: •A 20-year Swedish study shows that sun avoidance is as bad for the health as cigarette smoking. •A Spanish study shows that women who seek the sun have one-eleventh the hip fracture risk as those who avoid sun. •Men who work outdoors have half the risk of melanoma as those who work indoors. •Women who totally avoid the sun have 10-times the risk of breast cancer as those who embrace the sun. •Women who sunbathe regularly have half the risk of death during a 20-year period compared to those who stay indoors. •Sun exposure increases nitric oxide production, which leads to a decrease in heart attack risk. •Vitamin D, the sunshine vitamin, is essential to human survival, and sun exposure is the only natural way to obtain it. Sunbathing can produce 20,000 units of vitamin D in 20 minutes of whole-body exposure. •Sun exposure dramatically improves mood through the production of serotonin and endorphin. •Beyond vitamin D, sun exposure also stimulates the production of endorphin, nitric oxide and BDNF, all of which are vital to human health. •Regular sun exposure also reduces high blood pressure, heart disease, psoriasis and multiple sclerosis (MS). •As sunscreen use has increased dramatically, melanoma has INCREASED exponentially. For the scientific references and articles for the above statements, visit http://sunlightinstitute.org/

17-Feb-2017 at 19:08 GMT

Submit a comment

Your comment has been saved

Post a comment

Please note that any information that you supply is protected by our Privacy and Cookie Policy. Access to all documents and request for further information are available to all users at no costs, In order to provide you with this free service, William Reed Business Media SAS does share your information with companies that have content on this site. When you access a document or request further information from this site, your information maybe shared with the owners of that document or information.