Eight weeks of supplementation with the commercially available Oxyjun ingredient developed by Enovate Biolife Pvt. Ltd led to increases in left ventricular ejection fraction (LVEF), the measure of how much blood is being pumped out of the heart’s main pumping chamber (the left ventricle) with each contraction.
In addition, the Myocardial Performance Index decreased, wrote researchers in the American Journal of Therapeutics. MPI is a measure of cardiac function – the lower the value, the greater the oxygenation capacity and overall function.
“Based on the findings of the study, we deduce that [Oxyjun] was able to increase LVEF and decrease MPI without causing any cardiac injury,” wrote Robert Girandola from the University of Southern California and Shalini Srivastava from Enovate Biolife,. “This study successfully demonstrates the extract’s ability to enhance the performance and also protect the heart in young exercising adults.
“Currently, there is a void for a supplement which enhances the exercise performance effectively by improving the cardiac conditioning. [Oxyjun] has indeed shown some promising results to fulfill this unmet need of young athletes.”
The Terminalia arjuna extract is supplied by IN Ingredients and distributed by Prinova.
Drs Girandola and Srivastava recruited 32 healthy young men to participate in their double-blind placebo-controlled randomized clinical trial. The men were randomly assigned to receive placebo or 400 mg per day of Oxyjun for 56 days.
Results showed that, after 56 days, men in the Oxyjun group reported that the exercise conducted was easier and less stressful than the placebo group. The extract also led to a 3.7% greater LVEF after eight weeks, compared to placebo.
A potential anti-fatigue effect was observed for men receiving the bark extract, with reductions in scores of so-called rated perceived exertion (RPE), recorded.
Importantly, no adverse events were reported in the study.
“Based on the findings of the study, we deduce that [TA extract as Oxyjun] improved various central factors for physical endurance such as left ventricular ejection fraction, time to exhaustion and [Rated Perceived Exertion] score,” said Dr Girandola.
“This study successfully demonstrates the extract’s ability to enhance the performance and protect the heart in young exercising adults,” he added.
Source: American Journal of Therapeutics
Published online ahead of print
“Effect of E-OJ-01 on Cardiac Conditioning in Young Exercising Adults: A Randomized Controlled Trial”
Authors: R.N. Girandola, S. Srivastava